Huston received British Academy Award nominations for her work in the Woody Allen films Crimes and Misdemeanors (1989) and Manhattan Murder Mystery (1993). Among her other roles, she starred as Morticia Addams in The Addams Family (1991) and Addams Family Values (1993), receiving Golden Globe nominations for both, and played the Grand High Witch in the children's movie The Witches (1990). She has frequently collaborated with director Wes Anderson, including The Royal Tenenbaums (2001) and The Life Aquatic with Steve Zissou (2004). She is also the author of the book A Story Lately Told. Since 2008, Anjelica is Queen Clarion's voice.